Toxicological Assessment of Adansonia digitata L. Reveals a Favorable Safety Profile in In-vivo and In-vitro Models

Tayyaba Mumtaz; Ghazala H. Rizwani; Farhana Tasleem; Anum Fatima; Hammad Ahmed

doi:10.56810/jpbm.003.01.0086

Authors

Tayyaba Mumtaz Jinnah College of Pharmacy, Sohail University, Karachi
Ghazala H. Rizwani Director Hafiz Ilyas Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi
Farhana Tasleem Department of Pharmacognosy, Faculty of Pharmacy, Salim Habib University, Karachi
Anum Fatima Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi 75600
Hammad Ahmed Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Ziauddin University, Karachi 75600

DOI:

https://doi.org/10.56810/jpbm.003.01.0086

Keywords:

Natural plants, Adensonia digitata L, Acute toxicity, In vivo and In vitro models

Abstract

Natural plants are considered among the safest remedies and have been used for the treatment of various ailments since ancient times. However, due to their continued use, it is essential to provide scientific evidence supporting their safety profiles. The objective of this study was to evaluate the toxicological effects of Adansonia digitata L. leaf extracts using standard in vivo and in vitro models. Several assays were conducted, including the acute toxicity test, brine shrimp lethality assay, larval hatching assay, phytotoxic assay, insecticidal activity test, rearing technique, and cytotoxicity assay. The results of all tests indicated a significantly safe profile. It is therefore concluded that Adansonia digitata L. exhibits a high safety margin, as demonstrated by both in vivo and in vitro evaluations, and may be effectively utilized as a natural remedy for various diseases.